It’s even deeper and more exciting than this explanation, but in a nutshell, enzymes run the body and a handful of minerals are needed to activate and run these enzymes. Minerals are the keys to make enzymes work. When you are depleted in key minerals, there are NO keys to make these necessary enzymes work. For example, ATP needs to be holding Magnesium to make energy. Without Magnesium your cells gets stuck making exhaust -- why you feel “exhausted”. These enzymes need energy to run, without Magnesium there is no energy. You could say Magnesium is the mineral of motion and emotion!
We didn’t lose the enzyme to covert cholesterol to vitamin D, we’ve lost the much needed minerals needed in this delicate process and the enzymes can no longer do their job. They are now realizing that supplementing Vitamin D without Magnesium is dangerous -- lots of consequences up river!
Vitamin D Can't Be Metabolized Without Sufficient Magnesium Levels
"Vitamin D can't be metabolized without sufficient magnesium levels, meaning Vitamin D remains stored and inactive for as many as 50 percent of Americans. In addition, Vitamin D supplements can increase a person's calcium and phosphate levels even while they remain Vitamin D deficient. People may suffer from vascular calcification if their magnesium levels aren't high enough to prevent the complication.
People are taking Vitamin D supplements but don't realize how it gets metabolized. Without magnesium, Vitamin D is not really useful or safe," says study co-author Mohammed S. Razzaque, MBBS, PhD, a professor of pathology at Lake Erie College of Osteopathic Medicine.
Razzaque explains that consumption of Vitamin D supplements can increase a person's calcium and phosphate levels even if they remain Vitamin D deficient. The problem is people may suffer from vascular calcification if their magnesium levels aren't high enough to prevent the complication.
Patients with optimum magnesium levels require less Vitamin D supplementation to achieve sufficient Vitamin D levels. Magnesium also reduces osteoporosis, helping to mitigate the risk of bone fracture that can be attributed to low levels of Vitamin D, Razzaque noted.
Deficiency in either of these nutrients is reported to be associated with various disorders, including skeletal deformities, cardiovascular diseases, and metabolic syndrome.” Source - www.sciencedaily.com/releases/2018/02/180226122548.htm
New research finds that magnesium may hold the key to understanding how vitamin D levels relate to health and disease.
"New evidence shifts the focus onto magnesium, implicating it in playing a central role in determining how much vitamin D our bodies can make.
Dr. Qi Dai, a professor of medicine at Vanderbilt University Medical Center and the lead study author, previously reported on the relationship between magnesium intake and vitamin D levels in over 12,000 individuals taking part in the National Health and Nutrition Examination Survey (NHANES) 2001–2006 study.
Here, Dr. Dai and team found that individuals with high levels of magnesium intake, whether from dietary sources or taking supplements, were less likely to have low levels of vitamin D.
Importantly, the researchers also found a possible association between magnesium intake and a reduction in mortality, particularly when they looked at mortality due to cardiovascular disease and bowel cancer.
So, how does magnesium affect vitamin D biology in the body? It is a cofactor in the synthesis of vitamin D from both exposure to sunlight and dietary sources. "Magnesium deficiency shuts down the vitamin D synthesis and metabolism pathway," Dr. Dai explains.” Source - www.medicalnewstoday.com/articles/324022.php
Iron Liver Overload
Then you have liver iron overload that is where the first step in the conversion of cholesterol to vitamin D happens. If you’ve been following me on Instagram you will be reading about iron overload and it’s connection to every modern disease we suffer from and how we are getting so much more iron than our grandparents or great grandparents did. They started fortifying our food back in 1942 with iron shavings -- mainly wheat and grains (think breads and cereals). This is to a large degree why Paleo, Ancestral, low-carb and Keto diets are so effective in weight loss and regaining health, largely due to cutting out excess iron consumption. When you cut out iron and start to decrease your iron levels, inflammation (oxidative stress “rust”) goes way down.
Vitamin D Insufficiency and Liver Iron Concentration in Transfusion Dependent Hemoglobinopathies in British Columbia
“Patients with thalassemia major (TM) and other chronically transfused hereditary anemias are at increased risk of complications including endocrinopathies and bone disease due to iron overload. Vitamin D is important for bone health. Vitamin D deficiency is common in patients with transfusional iron overload, and the mechanism remains unclear. The first step in vitamin D metabolism, hydroxylation, occurs in the liver and liver iron overload may interfere with this step. This study investigates an association between degree of liver iron overload and vitamin D levels in patients with transfusion dependent hemoglobinopathies. Patients with TM, hemoglobin Eβ TM (Eβ TM), and congenital dyserythropiotc anemia (CDA) attending the Inherited Bleeding and Red Blood Cell Disorder Program in British Columbia (IBRBCD BC), Canada were identified. Included patients had an assessment of liver iron concentration (LIC) by MRI and endocrinology assessment including 25 hydroxy vitamin D level. Thirty patients were identified. The mean LIC was 5.13 mg/g dry weight (DW). Vitamin D deficiency/insufficiency was identified in 19 (63.3%). Eleven (36.7%) patients had an LIC ≥5 mg/gDW, 8 of whom had a vitamin D level <60 nmol/L, indicating moderate vitamin D insufficiency or deficiency. There was a significant association between LIC >5 mg/gDW and vitamin D level <60nmol/L (P= 0.027) and there was a significant inverse correlation between LIC and vitamin D (R=-0.33). These results indicate an association between increased LIC and vitamin D insufficiency/deficiency, suggesting that liver iron overload may indeed affect vitamin D metabolism. Prospective trials are needed to confirm these results.” Source - rossscience.org/ARTICLE/OJHMT-6-6.php
Inflammation and vitamin D: the infection connection
Vitamin D deficiency and inflammation increases in the face of supplementation. Pathogens, mold, bacteria, parasites all feed on a buffet of unbound (excess) iron. Sugar intake increases iron absorption. Iron eats Magnesium for breakfast and forces magnesium out of the cells. You need to constantly stay on top of your magnesium. 3,751 out of 9000 enzymes are dependent on magnesium.
“Low serum 25(OH)D is also found in healthy persons exposed to adequate sunlight. Despite increased vitamin D supplementation inflammatory diseases are increasing. The current method of determining vitamin D status may be at fault. The level of 25(OH)D does not always reflect the level of 1,25(OH)2D. Assessment of both metabolites often reveals elevated 1,25(OH)2D, indicating abnormal vitamin D endocrine function.” Source - www.ncbi.nlm.nih.gov/pmc/articles/PMC4160567/
Your skin is semi-permeable and can absorb and excrete certain substances with remarkable efficiency! Transdermal Magnesium Chloride is a quick and easy way to restore your magnesium levels and correct chronic degenerative conditions caused by magnesium deficiency.